Auer Rods - Acute Myelogenous Leukemia - Part 2

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More AML fun facts!

Cytogenetic abnormalities in AML may include t(8;21), inv(16), t(15;17), and monosomies/deletions in chromosomes 5 and 7. 

t(15;17) is associated with PML (acute promyelocytic leukemia) where there is a fusion of the PML protein with retinoic acid receptor-α (RARα). Remember to treat with ATRA. 

AML can also develop secondarily after treatment with topisomerase II inhibitors. This can result in MLL gene rearrangements on chromosome 11q23.